ROR1 | US Biological R2999-60 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

ROR1

catalog :

R2999-60

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

R2999-60

Product wo Prefix :

ROR1

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

ROR1 and ROR2 are orphan receptor tyrosine kinases that are most closely related to MuSK and the Trk family of neurotrophin receptors. They are characterized by the presence of extracellular Frizzled-like cysteine-rich domains and membrane-proximal Kringle domains, both of which are assumed to mediate protein-protein interactions (1-3). The ROR family RTKs are evolutionarily conserved among Caenorhabditis elegans, Drosophila, mice and humans (1,4). Although the functions of ROR kinases are unknown, similarities between ROR and MuSK and Trk kinases have led to speculation that ROR kinases regulate synaptic development. It was shown that CAM-1, a C. elegans ortholog of the ROR family RTKs plays several important roles in regulating cellular migration, polarity of asymmetric cell divisions, and axonal outgrowth of neurons during nematode development (4). mROR1 and mROR2 may play differential roles during the development of the nervous system (5). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

Synthetic peptide corresponding to the residues at the amino-terminal sequence of human ROR1. Species Sequence Homology: human

Specificity :

Recognizes transfected levels of mouse ROR1 proteins at ~135kD. Does not crossreact with ROR2.

Purity :

Purified by Protein A and immunoaffinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 0.15M sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 0.15M sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to the residues at the amino-terminal sequence of human ROR1. Species Sequence Homology: human Specificity: Recognizes transfected levels of mouse ROR1 proteins at ~135kD. Does not crossreact with ROR2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Al-Shawi, R., et al., Dev. Genes Evol. 211: 161–171 (2001). 2. Nomi, M., et al., Mol. Cell. Biol. 21: 8329–8235 (2001). 3. Roszmusz, E., et al., J. Biol. Chem. 276: 18,485–18,490 (2001). 4. Forrester, et al., Nature 400: 881–885 (1999). 5. Oishi, I., Genes Cells 4: 41–56 (1999).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/48/R2999-60_1.jpg