RAGE (Receptor for Advanced Glycosylation End Products, Advanced Glycosylation End Product-specific Receptor, AGER) discontinued | US Biological R1031-20D1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

RAGE (Receptor for Advanced Glycosylation End Products, Advanced Glycosylation End Product-specific Receptor, AGER) discontinued

catalog :

R1031-20D1

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

R1031-20D1

Product wo Prefix :

RAGE (Receptor for Advanced Glycosylation End Products, Advanced Glycosylation End Product-specific Receptor, AGER) discontinued

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

The receptor for advanced glycation end products (RAGE) is member of the immunoglobulin (Ig) superfamily. It can be expressed as full-length, membrane-bound RAGE isoform 1 or as a secreted sRAGE protein that lacks a transmembrane domain. RAGE is detected during early developmental stages and in the lung under normal physiological conditions (2) and is upregulated at sites of inflammation. Advanced glycation end products (AGEs) and a variety of other ligands interact with this receptor. Ligand binding activates full-length RAGE and initiates downstream signaling pathways that include activation of NF-kB, which leads to production of pro-inflammatory cytokines, and inflammation. Activation of these pathways has been implicated in various disease states including Alzheimer disease, diabetes, arthritis and atherosclerosis. Soluble RAGE can competitively bind RAGE ligands in the extracellular environment, which prevents ligand interaction with full-length RAGE at the cell surface. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunohistochemistry (Paraffin): 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

MGC22357

Immunogen :

Synthetic peptide corresponding to residues near the carboxy terminus of human RAGE isoform 1 protein.

Specificity :

Recognizes endogenous levels of total human RAGE 1 protein at ~58kD. Species Sequence Homology: monkey

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not Determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not Determined Form: Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues near the carboxy terminus of human RAGE isoform 1 protein. Specificity: Recognizes endogenous levels of total human RAGE 1 protein at ~58kD. Species Sequence Homology: monkey Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

IHC WB

Storage Temperature :

-20°C

Reference :

1. Bierhaus, A. et al. (2005) J Mol Med 83, 876-86.2. Brett, J. et al. (1993) Am J Pathol 143, 1699-712. 3. Sparvero, L.J. et al. (2009) J Transl Med 7, 17. 4. Lin, L. et al. (2009) Front Biosci 14, 1403-13

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/29/R1031-20D1_1.jpg