Rab7 | US Biological R0008-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Rab7

catalog :

R0008-41

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

R0008-41

Product wo Prefix :

Rab7

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Rab7 and Rab9 are members of the Ras superfamily of small Rab GTPases (1). Both proteins are located in late endosomes but exert different functions. Rab7 associates with the RIPL effector protein to control membrane trafficking from early to late endosome and to lysosomes (2,3). Rab7 also helps to regulate growth receptor endocytic trafficking and degradation (3,4), and maturation of phagosome and autophagic vacuoles (4-6). Rab9 interacts with its effector proteins p40 and TIP47 (7,8) to promote the MPRs (mannose 6-phosphate receptors)-associated lysosome enzyme transport between late endosomes and the trans Golgi network (9,10). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo Rt

Immunogen :

Synthetic peptide corresponding to residues surrounding Asp193 of human Rab7.

Specificity :

Recognizes endogenous levels of total human Rab7 protein. Species Crossreactivity: mouse and rat.

Purity :

Purified by peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues surrounding Asp193 of human Rab7. Specificity: Recognizes endogenous levels of total human Rab7 protein. Species Crossreactivity: mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Zerial, M. & McBride, H., Nat. Rev. Mol. Cell Biol. 2: 107–117 (2001). 2. Feng, Y., et al., J. Cell. Biol. 131: 1435–1452 (1995). 3. Méresse, S., et al., J. Cell. Sci. 108(11): 3349–3358 (1995). 4. Ceresa, B.P. & Bahr, S.J., J. Biol. Chem. 281: 1099–1106 (2006). 5. Jäger, S., et al., J. Cell. Sci. 117: 4837–4848 (2004). 6. Méresse, S., et al., EMBO J. 18: 4394–4403 (1999). 7. Díaz, E., et al., J. Cell. Biol. 138: 283–290 (1997). 8. Barbero, P., et al., J. Cell. Biol. 156: 511–518 (2002). 9. Lombardi, D., et al., EMBO J. 12: 677–682 (1993). 10. Riederer, M.A., et al., J. Cell. Biol. 125: 573–582 (1994).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/20/R0008-41_1.jpg