ProCollagen Type I C-Terminal Propeptide (PICP) | US Biological P9005-74E product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

ProCollagen Type I C-Terminal Propeptide (PICP)

catalog :

P9005-74E

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6F177 (18)

reactivity :

human

product information

Catalog Number :

P9005-74E

Product wo Prefix :

ProCollagen Type I C-Terminal Propeptide (PICP)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

6F177 (18)

Isotype :

IgG1,k

Desc1 :

Type I collagen is present in connective tissue and bone where it makes up about 90% of the organic matrix. Type I collagen is produced from type-I procollagen by the proteolytic cleavage of N- and C-telopeptides, which are released into the circulation. The propeptides can be measured in serum as markers of the production of trype-I collagen. Elevated values of these propeptides are found in serum from patients with various metabolic or malignant bone diseases. Procollagen type I C-terminal propeptide (PICP) has a molecular mass of ~100kD. Its normal concentration in serum depends on age and sex. Applications: Suitable for use in ELISA, Immunoprecipitation and Western Blot. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Recommended Pair: Capture: P9005-74D Detection: P9005-74E Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

PICP purified from second trimester amniotic fluid.

Specificity :

Recognizes native human ProCollagen Type I Propeptide (PICP).

Purity :

Purified by Protein A affinity chromatography from culture supernatant.

Form :

Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.

Concentration :

~1mg/ml

Desc2 :

Product Type: Mab Isotype: IgG1,k Clone No: 6F177 (18) Host: mouse Source: human Concentration: ~1mg/ml Form: Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide. Purity: Purified by Protein A affinity chromatography from culture supernatant. Immunogen: PICP purified from second trimester amniotic fluid. Specificity: Recognizes native human ProCollagen Type I Propeptide (PICP). Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IP WB

Storage Temperature :

-20°C

Reference :

1. Hertel NT, et al., (1993) Serum concentrations of type I and III procollagen propeptides in healthy children and girls with central precocious puberty during treatment with gonadotropin-releasing hormone analog and cyproterone acetate. J Clin Endocrinol Metab 76:924-927. 2. Kjeldsen J, et al., (2001) Collagen metabolites in the peripheral and splanchnic circulation of patients with Crohn disease. Scand J Gastroenterol 36:1193-1197. 3. Orum O, et al., (1996) Procollagen type I N-terminal propeptide (PINP) as an indicator of type I collagen metabolism: ELISA development, reference interval, and hypovitaminosis D induced hyperparathyroidism. Bone 19:157-163.