ProCollagen Type I C-Terminal Propeptide (PICP) | US Biological P9005-74C product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

ProCollagen Type I C-Terminal Propeptide (PICP)

catalog :

P9005-74C

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6F175 (4)

reactivity :

human

product information

Catalog Number :

P9005-74C

Product wo Prefix :

ProCollagen Type I C-Terminal Propeptide (PICP)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

6F175 (4)

Isotype :

IgG1,k

Desc1 :

Collagen type I is present in soft connective tissue and bone where it represents approximately 90% of the organic matrix. Collagen type I is produced from procollagen when two teloterminal propeptides are digested from the procursor and released into the circulation. The propeptide levels can be measured in serum as indicators of collagen production. Elevated values of these propeptides in serum are found in patients with various bone metabolism defects. Procollagen type I C-terminal propeptide (PICP) has a molecular weight of ~100kD and the normal range in serum is 100-300ug/ml. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Hybridoma: X63-Ag8.653 myeloma cells with spleen cells from Balb/c mice. Culture Medium: RPMI 1640 with 10% fetal calf serum Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

PICP purified from second trimester amniotic fluid.

Specificity :

Recognizes native human Procollagen type I C-terminal propeptide (PICP) from amniotic fluid.

Purity :

Purified by Protein A affinity chromatography from culture supernatant.

Form :

Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.

Concentration :

~1mg/ml

Desc2 :

Product Type: Mab Isotype: IgG1,k Clone No: 6F175 (4) Host: mouse Source: human Concentration: ~1mg/ml Form: Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide. Purity: Purified by Protein A affinity chromatography from culture supernatant. Immunogen: PICP purified from second trimester amniotic fluid. Specificity: Recognizes native human Procollagen type I C-terminal propeptide (PICP) from amniotic fluid. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Hertel NT, Stoltenberg M, Juul A, Main KM, Muller J, Nielsen CT, Lorenzen I, Skakkebaek NE (1993) Serum concentrations of type I and III procollagen propeptides in healthy children and girls with central precocious puberty during treatment with gonadotropin-releasing hormone analog and cyproterone acetate. J Clin Endocrinol Metab 76:924-927. 2. Kjeldsen J, Rasmussen M, Schaffalitzky de Muckadell OB, Kronborg O, Junker P (2001) Collagen metabolites in the peripheral and splanchnic circulation of patients with Crohn disease. Scand J Gastroenterol 36:1193-1197. 3. Orum O, Hansen M, Jensen CH, Sorensen HA, Jensen LB, Horslev-Petersen K, Teisner B (1996) Procollagen type I N-terminal propeptide (PINP) as an indicator of type I collagen metabolism: ELISA development, reference interval, and hypovitaminosis D induced hyperparathyroidism. Bone 19:157-163.