PRNP (Major Prion Protein, PrP27-30, PrP33-35C, ASCR, CD230, PRIP, PRP) | US Biological P8950-25K product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

PRNP (Major Prion Protein, PrP27-30, PrP33-35C, ASCR, CD230, PRIP, PRP)

catalog :

P8950-25K

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

product information

Catalog Number :

P8950-25K

Product wo Prefix :

PRNP (Major Prion Protein, PrP27-30, PrP33-35C, ASCR, CD230, PRIP, PRP)

Host :

goat

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Western Blot: 0.3-1ug/ml, observed in human brain lysates on ~25kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Bo Hu Po

Immunogen :

Synthetic peptide corresponding to C-SDYEDRYYREN, from human PRNP, at the internal region of the protein (NP_000302.1).

Specificity :

Recognizes human PRNP. Species sequence homology: Bovine and porcine.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-SDYEDRYYREN, from human PRNP, at the internal region of the protein (NP_000302.1). Specificity: Recognizes human PRNP. Species sequence homology: Bovine and porcine. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Ballerini C, Gourdain P, Bachy V, Blanchard N, Levavasseur E, Gregoire S, Fontes P, Aucouturier P, Hivroz C, Carnaud C. Functional Implication of Cellular Prion Protein in Antigen-Driven Interactions between T Cells and Dendritic Cells. J Immunol. 2006 Jun 15;176(12):7254-62.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/34/P8950-25K_1.jpg