Presenilin-1 | US Biological P6300-27 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Presenilin-1

catalog :

P6300-27

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

P6300-27

Product wo Prefix :

Presenilin-1

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer’s disease, probably functioning through its associated gamma-secretase activity for amyloid-beta protein processing (1,2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed N-terminal (34kD) and C-terminal (~20kD) fragments (2,3). Applications: Suitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:500 Immunoprecipitation: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Hu Mk

Immunogen :

Synthetic peptide corresponding to residues around valine 293 of human presenilin 1. Species sequence homology: mouse (100%)

Specificity :

Recognizes endogenous levels of the carboxy-terminal fragment of human presenilin 1 (~22kD). The antibody detects the full length protein (55kD) to a lesser extent. Species Crossreactivity: monkey.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues around valine 293 of human presenilin 1. Species sequence homology: mouse (100%) Specificity: Recognizes endogenous levels of the carboxy-terminal fragment of human presenilin 1 (~22kD). The antibody detects the full length protein (55kD) to a lesser extent. Species Crossreactivity: monkey. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IP WB

Storage Temperature :

-20°C

Reference :

(1) Haass, C. and DeStrooper, B. (1999) Science 286, 916–919. (2) Kimberly, W.T. et al. (2000) J. Biol. Chem. 275, 3173–3178. (3) Kim, T.W. et al. (1997) J. Biol. Chem. 272, 11006–11010.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/33/P6300-27_1.jpg