antibody

PGLYRP1 (Peptidoglycan Recognition Protein 1, Peptidoglycan Recognition Protein Short, PGRP-S, PGLYRP, PGRP, TNFSF3L, SBBI68, UNQ639/PRO1269)

P3292-05E

100 ug

polyclonal

domestic goat

nonconjugated

PGLYRP1 (Peptidoglycan Recognition Protein 1, Peptidoglycan Recognition Protein Short, PGRP-S, PGLYRP, PGRP, TNFSF3L, SBBI68, UNQ639/PRO1269)

goat

Pab

Antibodies

100 ug

IgG

The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood. PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein. However, PGRP-S may have another, as yet unidentified function because in humans it is expressed in the bone marrow 50-100 times higher than in neutrophils. Applications: Suitable for use in Peptide ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: Peptide ELISA: 1:4000 Western Blot: 0.3-1ug/ml, observed in lysates of cell line Jurkat on ~30kD bands Immunohistochemistry (Paraffin): 3-6ug/ml using human spleen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

Synthetic peptide corresponding to C-PGNQLYHLIQN, from C-terminal of human PGLYRP1. Species Sequence Homology: canine

Recognizes human PGLYRP1.

Purified by immunoaffinity chromatography

Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

~0.5mg/ml

Product Type: Pab Isotype: IgG Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-PGNQLYHLIQN, from C-terminal of human PGLYRP1. Species Sequence Homology: canine Specificity: Recognizes human PGLYRP1. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

-20°C

1. Lu X, Wang M, Qi J, Wang H, Li X, Gupta D, Dziarski R. Peptidoglycan recognition proteins are a new class of human bactericidal proteins. J Biol Chem. 2006 Mar 3;281(9):5895-907. Epub 2005 Dec 14.

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