Pepsinogen I | US Biological P3272-04A product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Pepsinogen I

catalog :

P3272-04A

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4C6.1

reactivity :

human

product information

Catalog Number :

P3272-04A

Product wo Prefix :

Pepsinogen I

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ug

Clone # USB :

4C6.1

Isotype :

IgG1

Desc1 :

Pepsinogen I is a group of precursor molecules for pepsin. These proteins are solely synthetized and secreted into gastric lumen by chief (pepsin) cells and mucous neck cells in the gastric corpus (oxyntic mucosa). In atrophic corpus gastritis these cells disappear resulting in a decrease of the serum level of pepsinogen I and in a reduction of the number of pepsinogen I positive cells in gastric biopsies. The presence of positive immunostaining for pepsinogen I is a highly reliable sign for the acid-secreting oxyntic glands. In gastric heterotopia of the duodenal bulb, but not in gastric metaplasia, the oxyntic-type glands give a positive immunohistochemical reaction for pepsinogen I. Applications: Suitable for use in Immunohistochemistry, Western Blot and ELISA. Other applications not tested. Recommended Dilution: Immunohistochemistry: Paraffin Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

Pepsinogen I purified from human tissue

Specificity :

Recognizes human Pepsinogen I. Does not crossreact with human Pepsinogen II.

Purity :

Ascites

Form :

Supplied as a liquid in PBS, 1% BSA, 0.09 % sodium azide.

Concentration :

~0.1mg/ml

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 4C6.1 Host: mouse Source: human Concentration: ~0.1mg/ml Form: Supplied as a liquid in PBS, 1% BSA, 0.09 % sodium azide. Purity: Serum Immunogen: Pepsinogen I purified from human tissue Specificity: Recognizes human Pepsinogen I. Does not crossreact with human Pepsinogen II. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

-20°C

Reference :

1. Varis K. Surveillance of pernicious anemia. In Precancerous Lesions of the Gastrointestinal Tract. Scherlock P, Morson PC, Barbara L, Veronesi U (eds), Raven Press, New York, 189-194, 1983. 2. Sipponen P, Kekki M, Haapakoski J, Ihamäki T, Siurala M. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross sectional data. Int. J. Cancer, 35: 173-177, 1985. 3. Borch K, Axelsson CK, Halgreen H, Damkjaer Nielsen MD, Ledin T, Szesci PB. The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis. Scand. J. Gastroenterol., 24: 870-876, 1989. 4. Varis K, Sipponen P, Laxén F, Samloff MI, Huttunen J, Taylor PR, Heinonen OP, Albanes D, Sande N, Virtamo V, Härkönen M, Helsinki Gastritis Study Group. Serum pepsinogen I in screening of atrophic corpus gastritis. Implications in early endoscopic diagnosis of gastric cancer and dysplasia. Scand. J. Gastroenterol., 2000. 5. Miki K, Ichinose M, Ishikawa KB, Yahagi N, Matsushima M, Kakei N, Tsukada S, Kido M, Ishihama S, Shimizu Y, Suzuki T, Kurokawa K. Clinical application of serum pepsinogen I and II levels for mass screening to detect gastric cancer. Jpn. J. Cancer Res., 84: 1086-1090, 1993.