antibody

NOTCH2 (Neurogenic Locus Notch Homolog Protein 2, Notch 2, hN2)

N5375-16A

100 ug

polyclonal

domestic goat

nonconjugated

NOTCH2 (Neurogenic Locus Notch Homolog Protein 2, Notch 2, hN2)

goat

Pab

Antibodies

100 ug

IgG

Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Notch family members share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Multiple human notch proteins (NOTCH1, NOTCH2, NOTCH3 and NOTCH4) have been identified and they function as a receptors for membrane bound ligands. Notch signaling is also linked to tumorigenesis as first demonstrated by the identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL). Since this discovery, aberrant Notch signaling has been suggested to be involved in a wide variety of human neoplasms. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Bo Ca Hu Mo Po Rt

Synthetic peptide corresponding to C-ERTPSHSGHLQGEH, from NOTCH2, at the internal region of the protein (NP_077719.2).

Recognizes NOTCH2. Species sequence homology: Bovine, canine, human, mouse, porcine and rat.

Purified by immunoaffinity chromatography

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

~0.5mg/ml

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-ERTPSHSGHLQGEH, from NOTCH2, at the internal region of the protein (NP_077719.2). Specificity: Recognizes NOTCH2. Species sequence homology: Bovine, canine, human, mouse, porcine and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E

-20°C

1. Schwarzmeier JD, Hubmann R, Duchler M, Jager U, Shehata M. Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia. Leuk Lymphoma. 2005 Feb;46(2):157-65.