Norrin (Norrie Disease Protein) | US Biological N4000-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Norrin (Norrie Disease Protein)

catalog :

N4000-80

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7H103

reactivity :

human

product information

Catalog Number :

N4000-80

Product wo Prefix :

Norrin (Norrie Disease Protein)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ug

Clone # USB :

7H103

Isotype :

IgG1

Desc1 :

Norrin is a secreted protein that has a C-terminal cysteine-knot motif. Although Norrin is unrelated to Wnt family proteins, it is a Frizzled-4-specific ligand that activates the canonical Wnt pathway through Frizzled-4 and LRP5 (LDL receptor-related protein). Mutations in Norrin are associated with Norrie disease and X-linked familial exudative vitroretinopathy. The amino acid sequence of human Norrin is 100% and 94% identical to rhesus macaque and mouse Norrin, respectively. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1ug/ml under reducing conditions only. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Hu Mo

Immunogen :

Recombinant protein corresponding to Lys25-Ser133 of human Norrin expressed in E. coli. Swiss/UniProt Accession: Q00604

Specificity :

Recognizes human Norrin. Species Crossreactivity: mouse

Purity :

Purified by Protein G affinity chromatography from hybridoma culture supernatant.

Form :

Supplied as a lyophilized powder from PBS, pH 7.4,5% trehalose. Reconstitute with 200ul sterile PBS.

Concentration :

~0.5mg/ml (after reconstitution)

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 7H103 Host: mouse Source: human Concentration: ~0.5mg/ml (after reconstitution) Form: Supplied as a lyophilized powder from PBS, pH 7.4,5% trehalose. Reconstitute with 200ul sterile PBS. Purity: Purified by Protein G affinity chromatography from hybridoma culture supernatant. Immunogen: Recombinant protein corresponding to Lys25-Ser133 of human Norrin expressed in E. coli. Swiss/UniProt Accession: Q00604 Specificity: Recognizes human Norrin. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C