NDRG1 (Protein NDRG1, Differentiation-related Gene 1 Protein, DRG-1, N-myc Downstream-regulated Gene 1 Protein, Nickel-specific Induction Protein Cap43, Reducing Agents and Tunicamycin-responsive Protein, RTP, Rit42, CAP43, DRG1) | US Biological N2915-52E product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

NDRG1 (Protein NDRG1, Differentiation-related Gene 1 Protein, DRG-1, N-myc Downstream-regulated Gene 1 Protein, Nickel-specific Induction Protein Cap43, Reducing Agents and Tunicamycin-responsive Protein, RTP, Rit42, CAP43, DRG1)

catalog :

N2915-52E

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

N2915-52E

Product wo Prefix :

URL USB :

www.usbio.net/antibodies/N2915-52E/NDRG1-Protein-NDRG1-Differentiationrelated-Gene-1-Protein-DRG1-Nmyc-Downstreamregulated-Gene-1-Protein-Nickelspecific-Induction-Protein-Cap43-Reducing-Agents-and-Tunicamycinresponsive-Protein-RTP-Rit42-CAP43-DRG1

Host :

goat

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

NDRG1 is a member of the emerging NDRG family involved in stress responses, hormone responses, cell growth, and differentiation. The NDRG1 gene is mapped to human chromosome 8q24.2 and encodes a cytosolic protein containing three unique tandem repeats of 10 hydrophilic aa near the C-terminus. Expression of NDRG1 is markedly upregulated in various cells under such conditions as cell differentiation, hypoxia and exposure to heavy metals. However, its expression is repressed by the Myc family transcription factors and after cellular transformation. Mutations in the NDRG1 gene are linked to the hereditary motor and sensory neuropathy. The protein is ubiquitously expressed in human and rat heart, brain, kidney, placenta, lung, liver, skeletal muscle, and pancreas. Applications:. Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution:. ELISA: 1:32,000. Western Blot: 0.1-0.3ug/ml, observed in lysates of human brain, kidney and testis on ~48kD bands. Immunohistochemistry (Paraffin): 2-5ug/ml. Optimal dilutions to be determined by the researcher. Storage and Stability:. May be stored at 4 C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Ca Hu Mo Rt

Immunogen :

Synthetic peptide corresponding to GNSAGPKSMEVSC, from human NDRG1, at C-terminal (NP_006087.2, NP_001128714.1).

Specificity :

Recognizes human NDRG1. Species sequence homology: Canine, mouse and rat.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab. Host: goat. Source: human. Concentration: ~0.5mg/ml. Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to GNSAGPKSMEVSC, from human NDRG1, at C-terminal (NP_006087.2, NP_001128714.1). Specificity: Recognizes human NDRG1. Species sequence homology: Canine, mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

-20 C

Reference :

1. Zhou D, Salnikow K, Costa M. Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res. 1998 May 15;58(10):2182-9.

Picture 1 File Name :

usbio-images.r.worldssl.net/prodimages/22/N2915-52E_1.jpg