Nerve Growth Factor (NGF) | US Biological N2050-03 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Nerve Growth Factor (NGF)

catalog :

N2050-03

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

N2050-03

Product wo Prefix :

Nerve Growth Factor (NGF)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Nerve growth factor (NGF) is a small, secreted protein and member of the neurotrophin family of growth factors that promote neuronal cell survival and differentiation (1). Producing cells release NGF that bind and activate TrkA high affinity receptors to mediate NGF-driven signaling. NGF also binds to a low affinity p75 (NTR) receptors, which belong to the death receptor family (2). Although NGF has been classically described as favoring neuron survival and differentiation, nerve growth factor can promote apoptosis in cells that contain p75 (NTR) and lack TrkA. NGF can induce neuron death in a variety of neurodegenerative conditions, including Alzheimer disease (3). Besides its neurotrophic actions, NGF has an effect on non-neuronal cells and may help mediate inflammation, angiogenesis, and stimulate breast cancer cell growth (4-6). NGF signaling is looking increasingly promising as potential drug targets for diseases. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Immunogen :

Synthetic peptide corresponding to residues surrounding Thr146 of human NGF (KLH).

Specificity :

Recognizes recombinant human NGF. It does not cross-react with other proteins.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to residues surrounding Thr146 of human NGF (KLH). Specificity: Recognizes recombinant human NGF. It does not cross-react with other proteins. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

(1) Lessmann, V. et al. (2003) Prog Neurobiol 69, 341–74. (2) Neet, K.E. and Campenot, R.B. (2001) Cell Mol Life Sci 58, 1021–35. (3) Lorigados-Pedre, L. and Bergado-Rosado, J. Rev Neurol 38, 957–71. (4) Frossard, N. et al. (2004) Eur J Pharmacol 500, 453–65. (5) Nico, B. et al. (2007) Microvasc Res [Epub ahead of print]. (6) Descamps, S. et al. (2001) J Biol Chem 276, 17864–70.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/38/N2050-03_1.jpg