Mitochondrial Antiviral Signaling Protein (MAVS, VISA) | US Biological M3990-04 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Mitochondrial Antiviral Signaling Protein (MAVS, VISA)

catalog :

M3990-04

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

M3990-04

Product wo Prefix :

Mitochondrial Antiviral Signaling Protein (MAVS, VISA)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

The mitochondrial antiviral signaling protein (MAVS, VISA) contributes to innate immunity by triggering IRF-3 and NF- B activation in response to viral infection, leading to the production of IFN- (1). The MAVS protein contains an N-terminal CARD domain and a C-terminal mitochondrial transmembrane domain. The MAVS adaptor protein plays a critical and specific role in viral defenses (2). MAVS acts downstream of the RIG-I RNA helicase and viral RNA sensor, leading to the recruitment of IKK , TRIF and TRAF6 (3,4). Some viruses have evolved strategies to circumvent these innate defenses by using proteases that cleave MAVS to prevent its mitochondrial localization (5,6). Applications: Suitable for use in Immunofluorescence (IF-IC), Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunofluorescence (IF-IC): 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Immunogen :

Synthetic peptide corresponding to residues at the C-terminus of human MAVS (KLH).

Specificity :

Detects endogenous levels of total human MAVS protein. Bands detected at 52 and 75kD.

Purity :

Purified by affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol. Purity: Purified by affinity chromatography. Immunogen: Synthetic peptide corresponding to residues at the C-terminus of human MAVS (KLH). Specificity: Detects endogenous levels of total human MAVS protein. Bands detected at 52 and 75kD. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

IF WB

Storage Temperature :

-20°C

Reference :

1. Seth, R.B. et al. (2005) Cell 122, 669-682.2. Sun, Q. et al. (2006) Immunity 24, 633-642.3. Xu, L.G. et al. (2005) Mol. Cell 19, 727-740.4. Yoneyama, M. et al. (2004) Nat. Immunol. 5, 730-737. 5. Lin, R. et al. (2006) J. Virol. 80, 6072-6083. 6. Chen, Z. et al. (2007) J. Virol. 81, 964-976.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/40/M3990-04_1.jpg