MALT1, CT (MLT1, Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1, Paracaspase 1) | US Biological M2148-01 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

MALT1, CT (MLT1, Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1, Paracaspase 1)

catalog :

M2148-01

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

M2148-01

Product wo Prefix :

MALT1, CT (MLT1, Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1, Paracaspase 1)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-kappaB and may contribute to the progression of MALT lymphomas. It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-kappaB, resulting in increased proliferation and inhibition of apoptosis. A common translocation in MALT B-cell non-Hodgkin lymphomas t(11;18)(q21;q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of MALT1. The API2-MALT1 fusion protein likely leads to deregulation of NF-kappaB, contributing to increased oncogenic potential. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo Rt

Immunogen :

Synthetic peptide corresponding to the C-terminal of mouse/rat MALT1.

Specificity :

Recognizes endogenous levels of total mouse MALT1 at ~90kD. Species Crossreactivity: human and rat

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not Determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: mouse Concentration: Not Determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to the C-terminal of mouse/rat MALT1. Specificity: Recognizes endogenous levels of total mouse MALT1 at ~90kD. Species Crossreactivity: human and rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

IP WB

Storage Temperature :

-20°C

Reference :

1. Akagi, T. et al. (1999) Oncogene 18, 5785-5794. 2. Uren, A.G. et al. (2000) Mol. Cell 6, 961-967. 3. Ruland, J. et al. (2003) Immunity 19, 749-758. 4. Nakagawa, M. et al. (2006) Leukemia 20, 929-936. 5. Che, T. et al. (2004) J. Biol. Chem. 279, 15870-15876. 6. Lucas, P.C. et al. (2001) J. Biol. Chem. 276, 19012-19019. 7. Ho, L. et al. (2005) Blood 105, 2891-2899.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/10/M2148-01_1.jpg