LRRK2 (Leucine-rich Repeat Serine/Threonine-protein Kinase 2, Dardarin, PARK8) | US Biological L4502-21T product information

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product summary

company name :

US Biological

product type :

antibody

product name :

LRRK2 (Leucine-rich Repeat Serine/Threonine-protein Kinase 2, Dardarin, PARK8)

catalog :

L4502-21T

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

L4502-21T

Product wo Prefix :

LRRK2 (Leucine-rich Repeat Serine/Threonine-protein Kinase 2, Dardarin, PARK8)

Host :

goat

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Applications: Suitable for use in Western Blot, ELISA, Immunocytochemistry and Immunohistochemistry. Other applications not tested. Recommended Dilutions: ELISA (Peptide): 1:64,000 Western Blot: 0.3-1ug/ml using human brain Immunohistochemistry (Paraffin): 1-2ug/ml using human brain (hippocampus). Requires HIER using sodium citrate buffer pH 6.0 Immunocytochemistry: human neurons Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Bo Hu

Immunogen :

Synthetic peptide corresponding to CELAEKMRRTSV, from human LRRK2, at the internal region (near the C-terminal) of the protein. Species Sequence Homology: bovine

Specificity :

Recognizes human LRRK2.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Isotype: IgG Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to CELAEKMRRTSV, from human LRRK2, at the internal region (near the C-terminal) of the protein. Species Sequence Homology: bovine Specificity: Recognizes human LRRK2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IC IHC WB

Storage Temperature :

-20°C

Reference :

1. Alegre-Abarrategui J, et al., RRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease. Neuropathol Appl Neurobiol. 2007 Oct 26. 2. Sharma S, et al., LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: A morphological and quantitative study. Neuropathol Appl Neurobiol. 2011 Jun 23. 3. Alegre-Abarrategui J, et al., LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet. 2009 Nov 1;18(21):4022-34.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/49/L4502-21T_1.jpg