LSP1 (Lymphocyte-specific Protein 1, 47kD Actin-binding Protein, 52kD Phosphoprotein, pp52, Lymphocyte-specific Antigen WP34, WP34) | US Biological L2030-30C product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

LSP1 (Lymphocyte-specific Protein 1, 47kD Actin-binding Protein, 52kD Phosphoprotein, pp52, Lymphocyte-specific Antigen WP34, WP34)

catalog :

L2030-30C

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

product information

Catalog Number :

L2030-30C

Product wo Prefix :

LSP1 (Lymphocyte-specific Protein 1, 47kD Actin-binding Protein, 52kD Phosphoprotein, pp52, Lymphocyte-specific Antigen WP34, WP34)

Host :

goat

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

Leukocyte-specific protein (LSP; also known as Lymphocyte-specific protein1, SP34 and pp52) is a 52kd filamentous-actin-binding intracellular phosphoprotein. LSP is localized to the internal surface of the plasma membrane, cytoplasm, and actin filaments. LSP expressed in various eukaryotic cell lines such as the melanoma cell line A7 but not in other hematopoietic lineages. Studies showed that LSP play a key role in anti-IgM-induced apoptosis of the B-cell lymphoma line as well as cytoskeleton-driven regulation. LSP contains a high-affinity F-actin binding site, which recently is identified in the basic C-terminal half. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Western Blot: 0.05-0.2ug/ml, observed in human lymph node, tonsil and peripheral blood mononucleocytes lysates on ~50kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Bo Ca Hu Mo Rt

Immunogen :

Synthetic peptide corresponding to C-RYKFVATGHGKYEKV, from LSP1, at C-terminal (NP_002330.1, NP_001013271.1).

Specificity :

Recognizes human LSP1. Species Crossreactivity: Mouse and rat. Species sequence homology: Bovine and canine.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-RYKFVATGHGKYEKV, from LSP1, at C-terminal (NP_002330.1, NP_001013271.1). Specificity: Recognizes human LSP1. Species Crossreactivity: Mouse and rat. Species sequence homology: Bovine and canine. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Geijtenbeek TB, Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. Nature immunology 2009 Oct 10(10):1081-8.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/28/L2030-30C_1.jpg