Lactoferrin (LTF, LF, GIG12, Lactotransferrin, Talalactoferrin) | US Biological L1021-80A product information

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product summary

company name :

US Biological

product type :

antibody

product name :

Lactoferrin (LTF, LF, GIG12, Lactotransferrin, Talalactoferrin)

catalog :

L1021-80A

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

L1021-80A

Product wo Prefix :

Lactoferrin (LTF, LF, GIG12, Lactotransferrin, Talalactoferrin)

Host :

goat

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

Lactoferrin is an iron binding glycoprotein with an approximate molecular weight of 80kD. The protein has two iron binding domains each housing one Fe 3+ and the synergistic CO 3 2- ion. The crystal structure form of human lactoferrin at 2.2A resolution exhibits 5330 protein atoms, 2Fe2+, 2CO 32- and 98 carbohydrate atoms. Lactoferrin is absorbed from intestine by apical side of the membrane and localized to the nuclei. Intravenous infusion of lactoferrin is protective against lethal doses of E. coli and induce bacterimia by a mechanism that downregulates neutrophil TNF alfa secretion. Recombinant human lactoferrin (rhLF), expressed and extracted from rice seed, is being evaluated for use as a dietary supplement to treat iron deficiency and/or iron deficiency induced anemia. Lactoferrin has been shown to have a role in the immune system and in early development of the embryo. A specific receptor for lactoferrin binding has been implicated in the human fetal intestine. Early embryonic localization of lactoferrin by IHC has suggested its presence in various tissues including intestinal epitheliuem, kiney, and various regions of the brain. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.05-0.2ug/ml, observed in human peripheral mononucleocyte lysates on ~85kD bands Immunohistochemistry (Paraffin): 2-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

Synthetic peptide corresponding to C-ENYKSQQSSDPDP, from human LTF, at the internal region of the protein (NP_002334.2).

Specificity :

Recognizes human LTF.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-ENYKSQQSSDPDP, from human LTF, at the internal region of the protein (NP_002334.2). Specificity: Recognizes human LTF. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

-20°C

Reference :

1. de la Rosa G, Yang D, Tewary P, Varadhachary A, Oppenheim JJ Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses. J Immunol. 2008 May 15;180(10):6868-76.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/44/L1021-80A_1.jpg