antibody

KCTD11 (BTB/POZ Domain-containing Protein KCTD11, C17orf36, REN)

K0091-11

100 ug

polyclonal

domestic goat

nonconjugated

human, mouse, rat

KCTD11 (BTB/POZ Domain-containing Protein KCTD11, C17orf36, REN)

goat

Pab

Antibodies

100 ug

IgG

Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Bo Ca Hu Mo Rt

Synthetic peptide corresponding to C-PEVEYGRLGLQP, from human KCTD11, at the internal region of the protein (NP_001002914.1).

Recognizes human KCTD11. Species sequence homology: Bovine, canine, mouse and rat.

Purified by immunoaffinity chromatography

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

~0.5mg/ml

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-PEVEYGRLGLQP, from human KCTD11, at the internal region of the protein (NP_001002914.1). Specificity: Recognizes human KCTD11. Species sequence homology: Bovine, canine, mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

-20°C

https://usbio-images.r.worldssl.net/prodimages/43/K0091-11_1.jpg