antibody

Interleukin 17 Receptor D (IL-17RD) (PE)

I8439-21E

100Tests

polyclonal

domestic goat

PE

Interleukin 17 Receptor D (IL-17RD) (PE)

goat

Pab

PE

Antibodies

100Tests

IgG

Interleukin 17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. The gene for this protein belongs to a synexpression group originally identified in zebrafish and SEF is expressed along with FGF-3, -8, sprouty-2 (SPRY2) and SPRY4. By alternate splicing, two transcript variants, potentially encoding three protein isoforms exist. One is a full-length long form, one a shortened form that uses an alternate start site, and one an alternate splice form that removes the classic signal sequence. These isoforms have different expression patterns, subcellular localization, and function. The membrane-bound long form of human IL-17 RD is synthesized as a 739aa precursor protein with a putative 27aa signal peptide, a 272aa extracellular domain, a 20aa transmembrane segment and a 420aa cytoplastic domain. The extracellular domain contains one Ig-like domain and a fibronectin type III motif. The cytoplasmic domain shares homology with the intracellular domains of IL-17 receptor family members and shows one TIR (Toll/IL-1 Receptor) domain and a putative TRAF6-binding motif. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry:10ul to label 1x10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months after receipt at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.

Hu

Recombinant protein corresponding to human Interleukin-17 Receptor D, extracellular domain, expressed in NSO cells

Recognizes human Interleukin-17 Receptor D.

Purified by immunoaffinity chromatography

Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).

~0.025mg/ml

Product Type: Pab Isotype: IgG Host: goat Source: human Concentration: ~0.025mg/ml Form: Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE). Purity: Purified by affinity chromatography. Immunogen: Recombinant protein corresponding to human Interleukin-17 Receptor D, extracellular domain, expressed in NSO cells Specificity: Recognizes human Interleukin-17 Receptor D. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

FC

4°C Do not freeze

1. Furthauer, M. et al., 2002, Nat. Cell Biol. 4:170. 2. Xiong, S. et al., 2003, J. Biol. Chem. 278:50273. 3. Yang, R-B. et al., 2003, J. Biol. Chem. 278:33232. 4. Preger, E. et al., 2003, Proc. Natl. Acad. Sci. USA 101:1229. 5. Lin, W. et al., 2002, Mech. Dev. 113:163. 6. Tsang, M. et al., 2002, Nat. Cell Biol. 4:165. 7. Kovalenko, D. et al., 2003, J. Biol. Chem. 278:14087. 8. Torii, S. et al., 2004, Dev. Cell 7:33. 9. Yang, X. et al., 2004, J. Biol. Chem. 279:38099.

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