Interleukin 17 Receptor (IL-17R, CTLA8, IL-17RA, Interleukin-17 Receptor A) (PE) | US Biological I8439-03B product information

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product summary

company name :

US Biological

product type :

antibody

product name :

Interleukin 17 Receptor (IL-17R, CTLA8, IL-17RA, Interleukin-17 Receptor A) (PE)

catalog :

I8439-03B

quantity :

100Tests

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

7H38

reactivity :

human

product information

Catalog Number :

I8439-03B

Product wo Prefix :

Interleukin 17 Receptor (IL-17R, CTLA8, IL-17RA, Interleukin-17 Receptor A) (PE)

Host :

mouse

Product Type :

Mab

Conjugate :

Category :

Antibodies

Size1 :

100Tests

Clone # USB :

7H38

Isotype :

IgG1

Desc1 :

Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine. IL-17 binds to IL-17 receptor (IL-17 R), which shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested. The hIL-17 R gene was localized to chromosome 22. Human IL-17 R is an 866 amino acid (aa) type I membrane glycoprotein with a 293aa extracellular domain, a 21aa carboxy-proximal transmembrane domain, and a 525aa cytoplasmic tail. The aa sequence of hIL-17 R is 69% identical to the mIL-17 R. The signaling events of IL-17 include activation of NF-kB and JNK, and require TNF receptor-associated factor 6 (TRAF6). Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10ul to label 1x10e5 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months after receipt at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.

Calc Crossreactivity :

Immunogen :

Recombinant protein corresponding to aa33-320 from human IL-17, expressed in NS0 cells (Q96F46).

Specificity :

Recognizes human IL-17. Does not crossreact with rmIL-17R, rmIL‑17B R, or rhIL‑17B R or rmIL-17 R.

Purity :

Purified by Protein G affinity chromatography from hybridoma culture supernatant.

Form :

Supplied as a liquid in PBS, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).

Concentration :

~0.025mg/ml

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 7H38 Host: mouse Source: human Concentration: ~0.025mg/ml Form: Supplied as a liquid in PBS, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE). Purity: Purified by Protein G affinity chromatography from hybridoma culture supernatant. Immunogen: Recombinant protein corresponding to aa33-320 from human IL-17, expressed in NS0 cells (Q96F46). Specificity: Recognizes human IL-17. Does not crossreact with rmIL-17R, rmIL‑17B R, or rhIL‑17B R or rmIL-17 R. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

4°C Do not freeze

Reference :

1. Yao, Z. et al., 1997, Cytokine 9:794 2. Schwander, R. et al., 2000, J. Exp. Med. 191:1233.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/38/I8439-03B_1.jpg