Integrin, beta8 | US Biological I7661-46B product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Integrin, beta8

catalog :

I7661-46B

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8H177

reactivity :

human

product information

Catalog Number :

I7661-46B

Product wo Prefix :

Integrin, beta8

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ug

Clone # USB :

8H177

Isotype :

IgG2b

Desc1 :

Integrin beta 8 (Integrin b8) is a 90kD type I transmembrane glycoprotein of the Integrin family of adhesion molecules. It associates with Integrin aV to form a receptor for vitronectin, fibrin, and the latency associated peptide (LAP). Binding to LAP promotes the proteolytic release of active TGF-b from LAP. Integrin aVb8 is required for vascular morphogenesis in the embryonic brain and yolk sac. Within the extracellular domain, human Integrin b8 shares 87% aa sequence identity with mouse and rat Integrin b8. Applications: Suitable for use in Flow Cytometry and Direct ELISA. Other applications not tested. Recommended Dilutions: Flow Cytometry: 0.25ug/10e6 cells. Tested with A172 human glioblastoma cell line. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Immunogen :

Recombinant protein corresponding to Glu43-Arg684 from human Integrin b8, expressed in NS0 cells.

Specificity :

Recognizes human Integrin b8. Does not react with recombinant human Integrins b1, b2, b3, b4, b5, b6, or b7 or recombinant mouse Integrin b8.

Purity :

Purified by Protein A affinity chromatography from hybridoma culture supernatant.

Form :

Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.

Concentration :

~0.5mg/ml (after reconstitution)

Desc2 :

Product Type: Mab Isotype: IgG2b Clone No: 8H177 Host: mouse Source: human Concentration: ~0.5mg/ml (after reconstitution) Form: Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS. Purity: Purified by Protein A affinity chromatography from hybridoma culture supernatant. Immunogen: Recombinant protein corresponding to Glu43-Arg684 from human Integrin b8, expressed in NS0 cells. Specificity: Recognizes human Integrin b8. Does not react with recombinant human Integrins b1, b2, b3, b4, b5, b6, or b7 or recombinant mouse Integrin b8. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC

Storage Temperature :

-20°C

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/16/I7661-46B_1.jpg