antibody

Insulin-Like Growth Factor Binding Protein 1 (IGF Binding Protein 1, IGFBP1, IGFBP-1, IBP1, IBP-1, Amniotic Fluid Binding Protein, AFBP, IGF-BP25, Placental Protein 12, PP12) discontinued

I7661-16B5

200 ug

monoclonal

mouse

nonconjugated

10D246

Insulin-Like Growth Factor Binding Protein 1 (IGF Binding Protein 1, IGFBP1, IGFBP-1, IBP1, IBP-1, Amniotic Fluid Binding Protein, AFBP, IGF-BP25, Placental Protein 12, PP12) discontinued

mouse

Mab

Antibodies

200 ug

10D246

IgG1

Insulin like growth factor binding protein 1 (IGFBP1) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). The IGFBP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The N terminal and C terminal regions are highly homologous among rat, human and bovine sequences. Contained within IGFBP1 and 2 is an integrin receptor recognition sequence (RGD) that is responsible for promoting cell migration by an IGF independent action. IGFBPs hold a central position in IGF ligand receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. IGFBPs will either inhibit or enhance the biological activities of IGF or act in an IGF independent manner. Post translational modification of IGFBPs, including phosphorylation and proteolysis, will modify the affinities of the binding proteins for IGF and may indirectly regulate IGF actions. IGFBP1 is expressed in liver, decidua, and kidneys and is the major IGF binding protein in human amnionic fluid. In hepatocytes, IGFBP1 production is regulated at the transcriptional level due to the effects of insulin and corticosteriods. IGFBP1 is the major determinant of the level of free IGF in serum. The expression of IGFBP1 is inhibited by insulin, IGFI, and IGFII and is stimulated by glucocorticoids, thyroid hormone, and epidermal growth factor (EGF), indicating an endocrine function. IGFBP1 shows inhibitory actions on cell proliferation and differentiation, presumably by interfering with the interactions between IGF and the IGF receptor (IGFR). Applications: Suitable for use in ELISA and IRMA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

Alpha Pregnancy Associated Endometrial Globulin, Binding Protein 25, Binding Protein 26, Binding Protein 28, Growth Hormone Independent Binding Protein, hIGFBP-1

Human IGFBP-1.

Recognizes human IGFBP-1 and has an affinity of 3x109 l/mol human IGFBP-1. Does not react with human CG, prolactin and APP.

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

~1mg/ml

Product Type: Mab Isotype: IgG1 Clone No: 10D246 Host: mouse Source: human Concentration: ~1mg/ml Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: Human IGFBP-1. Specificity: Recognizes human IGFBP-1 and has an affinity of 3x109 l/mol human IGFBP-1. Does not react with human CG, prolactin and APP. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E

-20°C