ICOS Ligand (CD275, Inducible T cell co-stimulator ligand, B7-H2, B7 homolog 2, B7-like protein Gl50, B7 related protein 1, B7H2, B7RP-1, B7RP1, GL50, ICOS LG , ICOSLG, KIAA0653, LICOS, Transmembrane protein B7 H2 ICOS ligand)(PE) | US Biological I0650-01F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

ICOS Ligand (CD275, Inducible T cell co-stimulator ligand, B7-H2, B7 homolog 2, B7-like protein Gl50, B7 related protein 1, B7H2, B7RP-1, B7RP1, GL50, ICOS LG , ICOSLG, KIAA0653, LICOS, Transmembrane protein B7 H2 ICOS ligand)(PE)

catalog :

I0650-01F

quantity :

100Tests

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

8H104

reactivity :

human

product information

Catalog Number :

I0650-01F

Product wo Prefix :

Host :

mouse

Product Type :

Mab

Conjugate :

Category :

Antibodies

Size1 :

100Tests

Clone # USB :

8H104

Isotype :

IgG2b

Desc1 :

Human ICOS Ligand, also called B7-H2, B7RP-1, B7h, LICOS, and GL50, is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. Among the family members, they share about 20-25% amino acid identity. Human and mouse ICOS Ligand share ~49% amino acid identity. ICOS Ligand has been identified as the ligand for ICOS, a member of the CD28 family of costimulatory receptors. Human ICOS Ligand is a 309 amino acid (aa) protein with a putative 18aa signal peptide, a 239aa extracellular domain, an 18aa transmembrane region and a 33aa cytoplasmic domain. Human ICOS Ligand is expressed constitutively on resting B cells, dendritic cells, and at low levels on monocytes. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 10ul labels 10e5 cells or 50ul of packed whole blood. Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

B7RP-1, B7h, LICOS, GL50

Immunogen :

Recombinant corresponding to human ICOS Ligand extracellular domain expressed in NS0 cells.

Specificity :

Recognizes human ICOS Ligand.

Purity :

Purified by Protein G affinity chromatography.

Form :

Supplied as a liquid in PBS, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).

Concentration :

As reported

Desc2 :

Product Type: Mab Isotype: IgG2b Clone No: 8H104 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE). Purity: Purified by Protein G affinity chromatography. Immunogen: Recombinant corresponding to human ICOS Ligand extracellular domain expressed in NS0 cells. Specificity: Recognizes human ICOS Ligand. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

4°C Do not freeze

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/11/I0650-01F_1.jpg