antibody

GSTM1, GSTM2 (Glutathione S-transferase Mu 1, GST HB Subunit 4, GST Class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GST1 / Glutathione S-transferase Mu 2, GST Class-mu 2, GSTM2-2, GST4)

G8135-38A

100 ug

polyclonal

domestic goat

nonconjugated

GSTM1, GSTM2 (Glutathione S-transferase Mu 1, GST HB Subunit 4, GST Class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GST1 / Glutathione S-transferase Mu 2, GST Class-mu 2, GSTM2-2, GST4)

goat

Pab

Antibodies

100 ug

IgG

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1000 Western Blot: 1-3ug/ml, observed in human liver lung lysates on ~26kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

Synthetic peptide corresponding to CVFSKMAVWGNK, from human GSTM1/GSTM2, at C-terminal (NP_000552.2, NP_666533.1, NP_000839.1).

Recognizes human GSTM1 and GSTM2.

Purified by immunoaffinity chromatography

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

~0.5mg/ml

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to CVFSKMAVWGNK, from human GSTM1/GSTM2, at C-terminal (NP_000552.2, NP_666533.1, NP_000839.1). Specificity: Recognizes human GSTM1 and GSTM2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

-20°C

1. Endo K, Uno S, Seki T, Ariga T, Kusumi Y, Mitsumata M, Yamada S, Makishima M. Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene. Toxicol Appl Pharmacol. 2008 Jul 15;230(2):135-43. Epub 2008 Feb 21.

https://usbio-images.r.worldssl.net/prodimages/9/G8135-38A_1.jpg