FOXA2 (Hepatocyte Nuclear Factor 3-beta, HNF-3-beta, HNF-3B, Forkhead Box Protein A2, Transcription Factor 3B, TCF-3B, HNF3B, TCF3B) | US Biological F9045-10C product information

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product summary

company name :

US Biological

product type :

antibody

product name :

FOXA2 (Hepatocyte Nuclear Factor 3-beta, HNF-3-beta, HNF-3B, Forkhead Box Protein A2, Transcription Factor 3B, TCF-3B, HNF3B, TCF3B)

catalog :

F9045-10C

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

product information

Catalog Number :

F9045-10C

Product wo Prefix :

FOXA2 (Hepatocyte Nuclear Factor 3-beta, HNF-3-beta, HNF-3B, Forkhead Box Protein A2, Transcription Factor 3B, TCF-3B, HNF3B, TCF3B)

Host :

goat

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:4000 Western Blot: 1-3ug/ml, observed in human liver lysates on ~60kD bands Immunohistochemistry (Paraffin): 4-8ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Rt

Immunogen :

Synthetic peptide corresponding to C-GVYSRPIMNSS, from human FOXA2, at C-terminal (NP_068556.2; NP_710141.1). Species sequence homology: mouse

Specificity :

Recognizes human FOXA2. Species Crossreactivity: rat

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Isotype: IgG Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-GVYSRPIMNSS, from human FOXA2, at C-terminal (NP_068556.2; NP_710141.1). Species sequence homology: mouse Specificity: Recognizes human FOXA2. Species Crossreactivity: rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

-20°C

Reference :

1. Nakamura K, Moore R, Negishi M, Sueyoshi T. Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver. J Biol Chem. 2007 Mar 30;282(13):9768-76. 2. McKinnon CM, Ravier MA, Rutter GA. FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells. J Biol Chem. 2006 Dec 22;281(51):39358-69.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/1/F9045-10C_1.png