FRS2 (Fibroblast Growth Factor Receptor Substrate 2, FGFR Substrate 2, FGFR-signaling Adaptor SNT, Suc1-associated Neurotrophic Factor Target 1, SNT-1) | US Biological F7000-05F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

FRS2 (Fibroblast Growth Factor Receptor Substrate 2, FGFR Substrate 2, FGFR-signaling Adaptor SNT, Suc1-associated Neurotrophic Factor Target 1, SNT-1)

catalog :

F7000-05F

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

F7000-05F

Product wo Prefix :

FRS2 (Fibroblast Growth Factor Receptor Substrate 2, FGFR Substrate 2, FGFR-signaling Adaptor SNT, Suc1-associated Neurotrophic Factor Target 1, SNT-1)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

Fibroblast growth factor receptor substrate 2 (FRS2) is a 70-90kD member of the FSR family of lipid-anchored docking protein. FRS2 contains Grb2 binding sites, a myristylation sequence and a PTP domain. Activation of FGFR leads to tyrosine phosphorylation of FRS2 and the binding of phosphorylated FRS2 to GRB2/SOS complexes. Once phosphorylated, FRS2 recruits SH2 domain-containing proteins including Grb2 and SHP-2 mediating downstream signalling. FRS2 thus, acts as an intermediary between FGF and Trk receptors that links receptor tyrosine kinase to Ras/MAPK signaling pathway. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo Rt

Immunogen :

Synthetic peptide corresponding to aa493 from human FRS2.

Specificity :

Recognizes human FRS2. Species Crossreactivity: mouse and rat.

Purity :

Purified by affinity chromatography.

Form :

Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol. Purity: Purified by affinity chromatography. Immunogen: Synthetic peptide corresponding to aa493 from human FRS2. Specificity: Recognizes human FRS2. Species Crossreactivity: mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/16/F7000-05F_1.jpg