FGFR1 (Fibroblast Growth Factor Receptor 1, FGFR-1, Basic Fibroblast Growth Factor Receptor 1, BFGFR, bFGF-R-1, Fms-like Tyrosine Kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR) | US Biological F4305-02J1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

FGFR1 (Fibroblast Growth Factor Receptor 1, FGFR-1, Basic Fibroblast Growth Factor Receptor 1, BFGFR, bFGF-R-1, Fms-like Tyrosine Kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR)

catalog :

F4305-02J1

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

F4305-02J1

Product wo Prefix :

Host :

goat

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

FGFR1, also known as fibroblast growth factor receptor 1, is a receptor membrane tyrosine kinase belonging to the protein kinase superfamily, Tyr protein kinase family and fibroblast growth factor receptor subfamily with three Ig-like C2-type (immunoglobulin-like) domains and a protein kinase domain. This enzyme acts as a receptor for basic fibroblast growth factor while a shorter form of the receptor could be a receptor for FGF1 (aFGF). Binding of FGFR1 is reported to play a role in the modulation of bone elongation and also in bone development and maintenance. It also mediates two independent signaling pathways in retinal pigment epithelial cells and regulates proliferation, differentiation, and maintenance of normal myocardium. Defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly and many more diseases. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.3-1ug/ml, observed in human breast lysates on ~75kD bands Immunohistochemistry (Paraffin): 4-6ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Bo Ca Hu

Immunogen :

Synthetic peptide corresponding to CLPRHPAQLANGGLKR, from human FGFR1, at C-terminal (NP_075598.2, NP_056934.2).

Specificity :

Recognizes human FGFR1. Species sequence homology: Bovine and canine.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to CLPRHPAQLANGGLKR, from human FGFR1, at C-terminal (NP_075598.2, NP_056934.2). Specificity: Recognizes human FGFR1. Species sequence homology: Bovine and canine. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

-20°C

Reference :

1. Torry DS, Mukherjea D, Arroyo J, Torry RJ. Expression and function of placenta growth factor: implications for abnormal placentation. J Soc Gynecol Investig. 2003 May;10(4):178-88.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/46/F4305-02J1_1.jpg