Fatty Acid Binding Protein 4 (FABP4, A-FABP) | US Biological F0019-82E product information

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product summary

company name :

US Biological

product type :

antibody

product name :

Fatty Acid Binding Protein 4 (FABP4, A-FABP)

catalog :

F0019-82E

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

F0019-82E

Product wo Prefix :

Fatty Acid Binding Protein 4 (FABP4, A-FABP)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Fatty acid binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones. They participate in the transport of fatty acids and other lipids to various cellular pathways. The predominant fatty acid binding protein found in adipocytes is FABP4, also called adipocyte fatty acid binding protein or aP2. FABP4 is also expressed in macrophages. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes. Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE). Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

Synthetic peptide corresponding to the sequence of mouse Fatty Acid Binding Protein 4.

Specificity :

Recognizes endogenous levels of total mouse Fatty Acid Binding Protein 4 at ~15kD.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not Determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: mouse Concentration: Not Determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to the sequence of mouse Fatty Acid Binding Protein 4. Specificity: Recognizes endogenous levels of total mouse Fatty Acid Binding Protein 4 at ~15kD. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Tuncman, G. et al. (2006) Proc. Natl. Acad. Sci. USA 103: 6970-6975. 2. Haunerland, N.H. and Spener, F. (2004) Prog. Lipid Res. 43: 328-349. 3. Makowski, L. et al. (2001) Nat. Med. 7: 699-705. 4. Hotamisligil, G.S. et al. (1996) Science 274: 1377-1379.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/24/F0019-82E_1.jpg