DUSP10 (Dual Specificity Protein Phosphatase 10, Mitogen-activated Protein Kinase Phosphatase 5, MAP Kinase Phosphatase 5, MKP-5, MKP5) | US Biological D9840-40G product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

DUSP10 (Dual Specificity Protein Phosphatase 10, Mitogen-activated Protein Kinase Phosphatase 5, MAP Kinase Phosphatase 5, MKP-5, MKP5)

catalog :

D9840-40G

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

D9840-40G

Product wo Prefix :

DUSP10 (Dual Specificity Protein Phosphatase 10, Mitogen-activated Protein Kinase Phosphatase 5, MAP Kinase Phosphatase 5, MKP-5, MKP5)

Host :

goat

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This protein is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Western Blot: 0.5-2ug/ml, human liver lysate observed on ~53kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Bo Ca Hu Mo Rt

Immunogen :

Synthetic peptide corresponding to CRILTPKLMGVETVV, from human DUSP10, at C-terminal (NP_009138.1, NP_653329.1, NP_653330.1).

Specificity :

Recognizes human DUSP10. Species sequence homology: Bovine, canine, mouse and rat.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to CRILTPKLMGVETVV, from human DUSP10, at C-terminal (NP_009138.1, NP_653329.1, NP_653330.1). Specificity: Recognizes human DUSP10. Species sequence homology: Bovine, canine, mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Kadoya T, Khurana A, Tcherpakov M, Bromberg KD, Didier C, Broday L, Asahara T, Bhoumik A, Ronai Z. JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. Mol Cell Biol. 2005 Oct;25(19):8619-30.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/5/D9840-40G_1.jpg