DcR3 (TR6, Decoy Receptor 3, TNFRSF6B, TR6, M68) | US Biological D1500-25B2 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

DcR3 (TR6, Decoy Receptor 3, TNFRSF6B, TR6, M68)

catalog :

D1500-25B2

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

D1500-25B2

Product wo Prefix :

DcR3 (TR6, Decoy Receptor 3, TNFRSF6B, TR6, M68)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5 and DR6, plays an important role in the regulation of apoptosis in various physiological systems. The receptors are activated by a family of cytokines that include TNF, FasL and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC) resulting in activation of caspases. Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2 and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand . Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Rt

Immunogen :

Synthetic peptide corresponding to residues near the N-terminus of human DcR3.

Specificity :

Recognizes endogenous levels of total human DcR3. Species crossreactivity: rat

Purity :

Purified by Protein A and peptide affinity chromatography

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not Determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not Determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography Immunogen: Synthetic peptide corresponding to residues near the N-terminus of human DcR3. Specificity: Recognizes endogenous levels of total human DcR3. Species crossreactivity: rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Nagata, S. (1997) Cell 88, 355–365. 2. Thorburn, A. (2004) Cell Signal 16, 139–144. 3. Sheridan, J.P. et al. (1997) Science 277, 818–821. 4. Marsters, S.A. et al. (1997) Curr. Biol. 7, 1003–1006. 5. Pitti, R.M. et al. (1998) Nature 396, 699–703. 6. Liu, X. et al. (2005) Cancer Res. 65, 9169–9175. 7. Spalding, A.C. et al. (2002) Oncogene 21, 260–271. 8. Bernard, D. et al. (2001) J. Biol. Chem. 276, 27322–27328.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/45/D1500-25B2_1.jpg