DcR1 (TRAIL-R3, TRID, LIT, TRAIL Decoy Receptor1) | US Biological D1499-01Q product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

DcR1 (TRAIL-R3, TRID, LIT, TRAIL Decoy Receptor1)

catalog :

D1499-01Q

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

D1499-01Q

Product wo Prefix :

DcR1 (TRAIL-R3, TRID, LIT, TRAIL Decoy Receptor1)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5 and DR6, plays an important role in the regulation of apoptosis in various physiological systems (1,2). The receptors are activated by a family of cytokines that include TNF, FasL and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC) resulting in activation of caspases. Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2 and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand (3-5). Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity (6-8). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Hu Mo Rt

Immunogen :

Synthetic peptide corresponding to residues near the C-terminus of human DcR1.

Specificity :

Detects endogenous levels of total human DcR1 protein. Species Crossreactivity: mouse and rat

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues near the C-terminus of human DcR1. Specificity: Detects endogenous levels of total human DcR1 protein. Species Crossreactivity: mouse and rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

(1) Nagata, S. (1997) Cell 88, 355–365. (2) Thorburn, A. (2004) Cell Signal 16, 139–144. (3) Sheridan, J.P. et al. (1997) Science 277, 818–821. (4) Marsters, S.A. et al. (1997) Curr. Biol. 7, 1003–1006. (5) Pitti, R.M. et al. (1998) Nature 396, 699–703. (6) Liu, X. et al. (2005) Cancer Res. 65, 9169–9175. (7) Spalding, A.C. et al. (2002) Oncogene 21, 260–271. (8) Bernard, D. et al. (2001) J. Biol. Chem. 276, 27322–27328.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/12/D1499-01Q_1.jpg