antibody

CXCR1 (C-X-C Chemokine Receptor Type 1, CXC-R1, CXCR-1, CDw128a, High Affinity Interleukin-8 Receptor A, IL-8R A, IL-8 Receptor Type 1, CD181, CMKAR1, IL8RA)

C8347-07G

100 ug

polyclonal

domestic goat

nonconjugated

CXCR1 (C-X-C Chemokine Receptor Type 1, CXC-R1, CXCR-1, CDw128a, High Affinity Interleukin-8 Receptor A, IL-8R A, IL-8 Receptor Type 1, CD181, CMKAR1, IL8RA)

goat

Pab

Antibodies

100 ug

IgG

CXCR1 is a 67-70kD seven-transmembrane protein, also known as IL-8 receptor A (IL-8RA), CD181, and CDw128a. It is a CXC chemokine receptor belongs to G protein-coupled receptor (CPCR) family. CXCR1 is expressed as homodimer or heterodimer with CXCR2 and found on granulocytes, NK cells, subset of T lymphocytes, mast cells, monocytes, endothelial cells, megakarocytes, and oligodendrocytes. The expression level of CXCR1 on monocytes is lower that of CXCR2. CXCR1 mediates nurophil activation and chemotaxis, megakaryocytic proliferation, and angiogenesis via binding its ligands including IL-8(CXCL8), NAP-2(CXCL7), GCP-2(CXCL6), and GRO-a(CXCL1). Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

Synthetic peptide corresponding to C-SKEFLARHRVTSY, from CXCR1, at C-terminal (NP_000625.1).

Recognizes CXCR1. Species sequence homology: Human.

Purified by immunoaffinity chromatography

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

~0.5mg/ml

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-SKEFLARHRVTSY, from CXCR1, at C-terminal (NP_000625.1). Specificity: Recognizes CXCR1. Species sequence homology: Human. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E

-20°C

1. Singh S, Nannuru KC, Sadanandam A, Varney ML, Singh RK, CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion. British journal of cancer 2009 May 100(10):1638-46.