CREB, phosphorylated (Ser121) (CREB1, CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1) | US Biological C7915-01J product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

CREB, phosphorylated (Ser121) (CREB1, CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1)

catalog :

C7915-01J

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

product information

Catalog Number :

C7915-01J

Product wo Prefix :

CREB, phosphorylated (Ser121) (CREB1, CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1)

Host :

rabbit

Product Type :

Pab

Antigen Modification :

Phosphorylated

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. CREB is also regulated by DNA-damaging stimuli and is directly phosphorylated on Ser-121 by the ataxia-telangiectasia-mutated protein kinase, ATM in response to ionizing radiation. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo

Alternate Name :

CREB1, CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1

Immunogen :

A phospho-peptide spanning the Ser-121 phosphorylation site of human CREB1, UniProt Accession #P16220

Specificity :

This antibody is specific for the Ser-121-phosphorylated form of CREB1. Species Crossreactivity: Reacts with human and mouse CREB1. Other species have not been tested.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris buffer containing 50% glycerol and 0.05% sodium azide.

Concentration :

~0.3mg/ml

Desc2 :

Product Type: Pab Host: rabbit Source: human Concentration: ~0.3mg/ml Form: Supplied as a liquid in Tris buffer containing 50% glycerol and 0.05% sodium azide. Purity: Purified by immunoaffinity chromatography. Immunogen: A phospho-peptide spanning the Ser-121 phosphorylation site of human CREB1, UniProt Accession #P16220 Specificity: This antibody is specific for the Ser-121-phosphorylated form of CREB1. Species Crossreactivity: Reacts with human and mouse CREB1. Other species have not been tested. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

IP WB

Storage Temperature :

-20°C

Reference :

1. Shi. Y., et al. Direct regulation of CREB transcriptional activity by ATM in response to DNA damage. PNAS. 101: 5898-5903 (2004). 2. Dodson, G.E., Tibbetts, R.S. DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. J. Biol. Chem. 281:1692-1697, 2006. 3. Shanware, N. P., Trinh, A. T., Williams, L. M., and Tibbetts, R. S. (2007) Coregulated Ataxia Telangiectasia-mutated and Casein Kinase Sites Modulate cAMP-response Element-binding Protein-Coactivator Interactions in Response to DNA Damage, 282, 6283-6291. 4. Shi, Y., Dodson, G. E., Mukhopadhyay, P. S., Shanware, N. P., Trinh, A. T., and Tibbetts, R. S. (2007) Identification of Carboxyl-terminal MCM3 Phosphorylation Sites Using Polyreactive Phosphospecific Antibodies, 282, 9236-9243.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/23/C7915-01J_1.jpg