Contactin-associated Protein 2 (Caspr2) | US Biological C7865-22 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Contactin-associated Protein 2 (Caspr2)

catalog :

C7865-22

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

C7865-22

Product wo Prefix :

Contactin-associated Protein 2 (Caspr2)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Contactin-associated protein 2 (Caspr2) is a type I transmembrane protein and member of the neurexin superfamily that mediates nervous system cell-cell interactions through the Neurexin IV-Caspr-Paranodin (NCP) complex. A multiprotein complex consisting of TAG-1, Caspr2, K+ channel, PSD95 and protein 4.1B mediates the molecular interactions at the juxtaparanodal region of myelinated axons, with homophilic TAG-1 interactions mediating the binding of this complex to glia. Caspr2 protein localizes to juxtaparanodal regions of myelinated axons where it forms a cis-complex with the immunoglobulin-like cell adhesion molecule TAG-1. Caspr2 also binds to Shaker K+ channels Kv1.1, Kv1.2, and their Kvβ2 subunit. A PDZ domain at the Caspr2 carboxy terminus mediates the Caspr2-K+ channel association. Caspr2 is required for proper K+ channel localization, as Caspr2 deletion causes the redistribution of channels along the internodes. Furthermore, Caspr2 binds to protein 4.1B and connects the protein complex to the axonal cytoskeleton. Mutations in the Caspr2 gene have been linked to focal epilepsy, cortical dysplasia and Gilles de la Tourette syndrome. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 using anti-rabbit secondary antibodies. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo Rt

Immunogen :

Synthetic peptide surrounding Glu1320 of human Caspr2.

Specificity :

Recognizes endogenous levels of total human Caspr2 protein at ~150kD. Species Crossreactivity: mouse and rat

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not Determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not Determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic peptide surrounding Glu1320 of human Caspr2. Specificity: Recognizes endogenous levels of total human Caspr2 protein at ~150kD. Species Crossreactivity: mouse and rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Poliak, S., et al., Neuron 24: 1037–1047 (1999). 2. Poliak, S., et al., J. Cell Biol. 162: 1149–1160 (2003). 3. Traka, M., et al., J. Cell Biol. 162: 1161–1172 (2003). 4. Denisenko-Nehrbass, N., et al., Eur. J. Neurosci. 17: 411–416 (2003). 5. Verkerk, A.J., et al., Genomics 82: 1–9 (2003). 6. Strauss, K.A., et al., N. Engl. J. Med. 354: 1370–1377 (2006).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/46/C7865-22_1.jpg