Complement C3 (C3c, Complement Component C3c, C3/C3c, Acylation Stimulating Protein Cleavage Product, ASP, Complement Component 3, Complement Factor 3, CPAMD1) | US Biological C7850-14L product information

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product summary

company name :

US Biological

product type :

antibody

product name :

Complement C3 (C3c, Complement Component C3c, C3/C3c, Acylation Stimulating Protein Cleavage Product, ASP, Complement Component 3, Complement Factor 3, CPAMD1)

catalog :

C7850-14L

quantity :

1 ml

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

C7850-14L

Product wo Prefix :

Complement C3 (C3c, Complement Component C3c, C3/C3c, Acylation Stimulating Protein Cleavage Product, ASP, Complement Component 3, Complement Factor 3, CPAMD1)

Host :

sheep

Product Type :

Pab

Category :

Antibodies

Size1 :

1 ml

Isotype :

IgG

Desc1 :

Complement 3c is a polypeptide fragment which is present in C3. C3 plays a central role in the activation of the complement system. Processing of C3 by C3 convertase is the central reaction in both classical and alternative complement pathways, resulting in C3a and C3b. C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates, and help to initiate the complement cascade, potentially resulting in cellular apoptosis. C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c and C3dg. Defects in C3 can result in susceptibility to pyogenic infection. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 1:50 ELISA: 1:400 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

Native human C3c purified from serum

Specificity :

Recognizes human C3c. Shows minimal reactivity with related serum proteins.

Purity :

Purified by Protein G affinity chromatography.

Form :

Supplied as a liquid in PBS, 0.09% sodium azide.

Concentration :

~5mg/ml

Desc2 :

Product Type: Pab Isotype: IgG Host: sheep Source: human Concentration: ~5mg/ml Form: Supplied as a liquid in PBS, 0.09% sodium azide. Purity: Purified by Protein G affinity chromatography. Immunogen: Native human C3c purified from serum Specificity: Recognizes human C3c. Shows minimal reactivity with related serum proteins. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC

Storage Temperature :

-20°C

Reference :

1. Janssen, B. et al. (2005) Structures of complement component C3 provide insights into the function and evolution of immunity. Nature 437: 505511.