Cofilin | US Biological C7506-10A product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Cofilin

catalog :

C7506-10A

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

C7506-10A

Product wo Prefix :

Cofilin

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Cofilin and ADF (actin-depolymerization factor) are members of a family of essential conserved small actin-binding proteins that play pivotal roles in cytokinesis, endocytosis, embryonic development, stress response and tissue regeneration (1). In response to stimuli, cofilin promotes the regeneration of actin filaments by severing preexisting filaments (2). The severing activity of cofilin is inhibited by LIMK or TESK phosphorylation at Ser3 of cofilin (3-5). Phosphorylation at Ser3 also regulates cofilin translocation from the nucleus to the cytoplasm (6). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Bo Hu Mk Mo Rt

Immunogen :

Synthetic peptide corresponding to residues surrounding Asp59 of human cofilin.

Specificity :

Recognizes endogenous levels of total cofilin protein, Mol. Wt.: 19kD. Species Crossreactivity: mouse, rat, monkey, and bovine.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues surrounding Asp59 of human cofilin. Specificity: Recognizes endogenous levels of total cofilin protein, Mol. Wt.: 19kD. Species Crossreactivity: mouse, rat, monkey, and bovine. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Carlier, M. et al. (1999) J. Biol. Chem. 274:33827–33830. 2. Condeelis, J. (2001) Trends Cell Biol. 11:288–293. 3. Arber, S. et al. (1998) Nature 393:805–809. 4. Yang, N. et al. (1998) Nature 393:809–812. 5. Toshima, J. et al. (2001) J. Biol. Chem. 276:31449–31458. 6. Nebl, G. et al. (1996) J. Biol. Chem. 271:26276–26280.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/30/C7506-10A_1.jpg