CDK5 (Cyclin-Dependent Kinase 5, Cell Division Protein Kinase 5, Cyclin-dependent Kinase 5, Serine/Threonine-protein Kinase PSSALRE, Tau Protein Kinase II Catalytic Subunit, TPKII Catalytic Subunit) | US Biological C2575-10B product information

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product summary

company name :

US Biological

product type :

antibody

product name :

CDK5 (Cyclin-Dependent Kinase 5, Cell Division Protein Kinase 5, Cyclin-dependent Kinase 5, Serine/Threonine-protein Kinase PSSALRE, Tau Protein Kinase II Catalytic Subunit, TPKII Catalytic Subunit)

catalog :

C2575-10B

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

C2575-10B

Product wo Prefix :

CDK5 (Cyclin-Dependent Kinase 5, Cell Division Protein Kinase 5, Cyclin-dependent Kinase 5, Serine/Threonine-protein Kinase PSSALRE, Tau Protein Kinase II Catalytic Subunit, TPKII Catalytic Subunit)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Cyclin-dependent kinase-5(CDK5) is a member of the cyclin-dependent kinase family of serine/threonine kinases. Its mRNA and protein are expressed in the kidneys, testes, and ovaries. And Its activity has been detected almost exclusively in brain extracts. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity; however, Cdk5 is not activated by cyclins. Instead, Cdk5 activity requires association with one of two brain-specific regulatory subunits, called p35 and p39. These two activators regulate the spatial and temporal expression of active Cdk5, restricting its activity primarily to post-mitotic neurons. FunctionProbably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: SH-SY5Y Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo Rt

Immunogen :

Recombinant corresponding to human CDK5, His-tagged, expressed in Baculovirus expressed insect cells.

Specificity :

Recognizes human CDK5. Species Crossreactivity: mouse and rat.

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol. Purity: Purified by Protein A affinity chromatography. Immunogen: Recombinant corresponding to human CDK5, His-tagged, expressed in Baculovirus expressed insect cells. Specificity: Recognizes human CDK5. Species Crossreactivity: mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Shirley B. Shelton and gail V.W. Johnson 2004 Journal of Neurlchemistry 88:1313-1326. 2. Jonathan C Cruz and Li-Huei Tsai 2004 Current Poinion in Neurobiology 14:390-394. 3. Deanna S. Smith, Paul L. Greer, and Li-Huei Tsai 2001 Cell Growth & Differentiation 12:277-283.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/2/C2575-10B_1.jpg