cdc42 (Ras-related C3 botulinum toxin substrate 1) | US Biological C2562-12B product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

cdc42 (Ras-related C3 botulinum toxin substrate 1)

catalog :

C2562-12B

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

C2562-12B

Product wo Prefix :

cdc42 (Ras-related C3 botulinum toxin substrate 1)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Rac1 and cdc42 are members of the Rho-GTPase family. They play key roles in cytoskeletal reorganization, membrane trafficking, transcriptional regulation, cell growth and development. It has been established that GTP binding stimulates the activity of Rac1/cdc42. A putative Akt phosphorylation site at Ser71 of Rac1/cdc42 has been identified and confirmed by in vitro kinase assay (1). Phosphorylation at this site may inhibit GTP binding of Rac1, attenuating the signal transduction pathway downstream of Rac1 (1). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Bo Hu Mk Mo Rt

Immunogen :

Synthetic peptide (KLH-coupled) corresponding to residues surrounding Lys135 of human Cdc42. Species sequence homology: chicken, canine, Xenopus, and zebrafish

Specificity :

Recognizes endogenous levels of total human Cdc42 protein. The antibody does not cross-react with other GTPases. Species Crossreactivity: monkey, mouse, rat and bovine.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic peptide (KLH-coupled) corresponding to residues surrounding Lys135 of human Cdc42. Species sequence homology: chicken, canine, Xenopus, and zebrafish Specificity: Recognizes endogenous levels of total human Cdc42 protein. The antibody does not cross-react with other GTPases. Species Crossreactivity: monkey, mouse, rat and bovine. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Kwon, T. et al. (2000) J. Biol. Chem. 275, 423–428.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/49/C2562-12B_1.jpg