CD105 (Endoglin) | US Biological C2446-53 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

CD105 (Endoglin)

catalog :

C2446-53

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

product information

Catalog Number :

C2446-53

Product wo Prefix :

CD105 (Endoglin)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-beta receptor complex, functioning in related signaling pathways (1,2). Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported in wound healing, tumor vascularization, inflammatory tissues and in developing embryos (1-4). Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6). Application: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:1000, incubate membrane with diluted antibody in TBS, 5% BSA, 0.1% Tween-20 at 4°C with gentle shaking, overnight. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

Synthetic peptide corresponding to residues surrounding Pro430 of mouse endoglin.

Specificity :

Recognizes transfected levels of mouse endoglin.

Purity :

Purified by peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: mouse Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues surrounding Pro430 of mouse endoglin. Specificity: Recognizes transfected levels of mouse endoglin. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Bernabeu, C. et al. (2007) J Cell Biochem 102:1375–88. 2. Zhu, Y. et al. (2003) Stroke 34:2483–8. 3. Quintanilla, M. et al. (2003) Oncogene 22:5976–85. 4. Dallas, N.A. et al. (2008) Clin Cancer Res 14:1931–7. 5. ten Dijke, P. et al. (2008) Angiogenesis 11:79–89. 6. Fernández-L, A. et al. (2006) Clin Med Res 4:66–78.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/0/C2446-53_1.jpg