CD104 (Integrin beta4) | US Biological C2446-01J product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

CD104 (Integrin beta4)

catalog :

C2446-01J

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

C2446-01J

Product wo Prefix :

CD104 (Integrin beta4)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Integrins are alpha/beta heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 alpha and 8 beta subunits that form 24 known integrins with distinct tissue distribution and over- lapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside- out signaling) (1,2). Integrin beta 4 pairs with integrin α6 on the cell surface mem- brane to form the integrin alpha6beta4 heterodimer, an important laminin receptor that is essential for hemidesmosome formation and the support of stable adhesions between basal epithelial cells and the basement membrane (4,5). Integrin beta 4 is an important component in several growth factor induced signaling pathways that are involved in tumorigenesis and invasive cell growth (6,7). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Immunogen :

Synthetic peptide corresponding to residues surrounding Ser1812 of human integrin beta4 protein.

Specificity :

Recognizes endogenous levels of total human integrin beta 4.

Purity :

Purified by peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues surrounding Ser1812 of human integrin beta4 protein. Specificity: Recognizes endogenous levels of total human integrin beta 4. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Liu, S. et al. (2000) J Cell Sci 113(20):3563–71. 2. Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2:91–100. 3. van der Flier, A. and Sonnenberg, A. (2001) Cell Tissue Res 305:285–98. 4. Schaapveld, R.Q. et al. (1998) J Cell Biol 142:271–84. 5. Litjens, S.H. et al. (2006) Trends Cell Biol 16:376–83. 6. Guo, W. et al. (2006) Cell 126:489–502. 7. Bertotti, A. et al. (2006) J Cell Biol 175:993–1003.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/15/C2446-01J_1.jpg