CD49d (Integrin alpha4) | US Biological C2404-71D product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

CD49d (Integrin alpha4)

catalog :

C2404-71D

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

C2404-71D

Product wo Prefix :

CD49d (Integrin alpha4)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Integrins are alpha/beta heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 alpha and 8 beta subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunoprecipitation: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Immunogen :

Synthetic peptide corresponding to residues surrounding Ser1027 of human integrin alpha4.

Specificity :

Recognizes endogenous levels of human integrin alpha4 mature protein (150kD), alpha4 precursor protein (140kD), as well as 70kD cleaved C-terminal alpha 4 fragment.

Purity :

Purified by peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues surrounding Ser1027 of human integrin alpha4. Specificity: Recognizes endogenous levels of human integrin alpha4 mature protein (150kD), alpha4 precursor protein (140kD), as well as 70kD cleaved C-terminal alpha 4 fragment. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

IP WB

Storage Temperature :

-20°C

Reference :

1. Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2:91–100. 2. Liu, S. et al. (2000) J Cell Sci 113(20):3563–71. 3. Plow, E.F. et al. (2000) J Biol Chem 275:21785–8. 4. Bonder, C.S. et al. (2005) Immunity 23:153–63. 5. Arroyo, A.G. et al. (1999) Immunity 11:555–66. 6. Yang, J.T. et al. (1995) Development 121:549–60. 7. Nishiya, N. et al. (2005) Nat Cell Biol 7:343–52. 8. Alon, R. et al. (2005) J Cell Biol 171:1073–84. 9. Lanzarotto, F. et al. (2006) Drugs 66:1179–89. 10. Bartt, R.E. (2006) Curr Opin Neurol 19:341–9. 11. Teixidó, J. et al. (1992) J Biol Chem 267:1786–91. 12. Pujades, C. et al. (1996) Biochem J 313(3):899–908.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/34/C2404-71D_1.jpg