CACNA1C (Voltage-dependent L-type Calcium Channel Subunit alpha-1C, Calcium Channel, L Type, alpha-1 Polypeptide, Isoform 1, Cardiac Muscle, Voltage-gated Calcium Channel Subunit alpha Cav1.2, CACH2, CACN2, CACNL1A1, CCHL1A1) | US Biological C2097-85J product information

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product summary

company name :

US Biological

product type :

antibody

product name :

CACNA1C (Voltage-dependent L-type Calcium Channel Subunit alpha-1C, Calcium Channel, L Type, alpha-1 Polypeptide, Isoform 1, Cardiac Muscle, Voltage-gated Calcium Channel Subunit alpha Cav1.2, CACH2, CACN2, CACNL1A1, CCHL1A1)

catalog :

C2097-85J

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

C2097-85J

Product wo Prefix :

Host :

goat

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Many alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Western Blot: 0.5-1.5ug/ml, observed in human heart and skeletal muscle lysates on ~200kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

Synthetic peptide corresponding to C-RARGRPSEEELQD, from human CACNA1C, at C-terminal (NP_000710.5, NP_955630.2, NP_001161097.1).

Specificity :

Recognizes human CACNA1C.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-RARGRPSEEELQD, from human CACNA1C, at C-terminal (NP_000710.5, NP_955630.2, NP_001161097.1). Specificity: Recognizes human CACNA1C. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Saud ZA, Minobe E, Wang WY, Han DY, Horiuchi M, Hao LY, Kameyama M. Calpastatin binds to a calmodulin-binding site of cardiac Cav1.2 Ca2+ channels. Biochem Biophys Res Commun. 2007 Dec 14;364(2):372-7. Epub 2007 Oct 15.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/16/C2097-85J_1.jpg