antibody

CACNB4 (Voltage-dependent L-type Calcium Channel Subunit beta-4, CAB4, Calcium Channel Voltage-dependent Subunit beta 4, CACNLB4)

C0104-80Q2

100 ug

polyclonal

domestic goat

nonconjugated

human, mouse, rat

CACNB4 (Voltage-dependent L-type Calcium Channel Subunit beta-4, CAB4, Calcium Channel Voltage-dependent Subunit beta 4, CACNLB4)

goat

Pab

Antibodies

100 ug

IgG

This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:4000 Western Blot: 0.2-0.6ug/ml, observed in human bone marrow lysates on ~55-60kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Ca Hu Mo Rt

Synthetic peptide corresponding to C-DYPDSYQDTYKPH, from human CACNB4, at the internal region (near C-terminal) of the protein (NP_001005747.1, NP_000717.2, NP_001005746.1).

Recognizes human CACNB4. Species sequence homology: Canine, mouse and rat.

Purified by immunoaffinity chromatography

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

~0.5mg/ml

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-DYPDSYQDTYKPH, from human CACNB4, at the internal region (near C-terminal) of the protein (NP_001005747.1, NP_000717.2, NP_001005746.1). Specificity: Recognizes human CACNB4. Species sequence homology: Canine, mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

-20°C

1. Escayg A, Jones JM, Kearney JA, Hitchcock PF, Meisler MH. Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic. Genomics. 1998 May 15;50(1):14-22.

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