ATM (Serine-protein Kinase ATM, Ataxia Telangiectasia Mutated, A-T mutated) | US Biological A4000-25W product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

ATM (Serine-protein Kinase ATM, Ataxia Telangiectasia Mutated, A-T mutated)

catalog :

A4000-25W

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

A4000-25W

Product wo Prefix :

ATM (Serine-protein Kinase ATM, Ataxia Telangiectasia Mutated, A-T mutated)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

ATM is a 350-370kD member of the ATM subfamily, PI3/PI4-kinase family of enzymes. It is ubiquitously expressed, and serves as a DNA damage sensor. ATM is activated via autophosphorylation at double strand breaks. Following activation, multiple substrates are phosphorylated, including Chk2, and ATR is recruited and activated as part of an integrated repair circuit. Human ATM is 3056aa in length. It contains one FAT (focal adhesion targeting) domain aa1960-2566, a PI-3/PI-4 kinase catalytic domain aa2712-2962 and a second, C-terminal FAT domain aa3024-3056. There are at least six Ser and four Thr utilized phosphorylation sites, and one critical acetylation activation site at aa3016. There are at least four potential splice variants. One shows a Trp substitution for aa536-3056, a second contains an eight aa substitution for aa2506-3056, a third possesses a five aa substitution for aa1637-3056, while a fourth contains a premature truncation after aa2756. Over aa2138-2400, human ATM shares 82% aa identity with mouse ATM. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo

Immunogen :

Synthetic peptide corresponding to human Ataxia Telangiectasia Mutated (ATM).

Specificity :

Recognizes human ATM. Species Crossreactivity: mouse.

Purity :

Purified by affinity chromatography.

Form :

Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol. Purity: Purified by affinity chromatography. Immunogen: Synthetic peptide corresponding to human Ataxia Telangiectasia Mutated (ATM). Specificity: Recognizes human ATM. Species Crossreactivity: mouse. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

IP WB

Storage Temperature :

-20°C