antibody

ALDH1A1, CT (Retinal Dehydrogenase 1, RalDH1, RALDH 1, Aldehyde Dehydrogenase Family 1 Member A1, Aldehyde Dehydrogenase, Cytosolic, ALHDII, ALDH-E1, ALDH1A1, ALDC, ALDH1, PUMB1)

A1334-33X

100 ug

polyclonal

domestic goat

nonconjugated

human, mouse, rat

ALDH1A1, CT (Retinal Dehydrogenase 1, RalDH1, RALDH 1, Aldehyde Dehydrogenase Family 1 Member A1, Aldehyde Dehydrogenase, Cytosolic, ALHDII, ALDH-E1, ALDH1A1, ALDC, ALDH1, PUMB1)

goat

Pab

Antibodies

100 ug

IgG

ALDH1A1 belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. Applications: Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Western Blot: 0.03-0.1ug/ml, human liver lysates observed on ~55kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Bo Ca Hu Mo Rt

Synthetic peptide corresponding to C-EVKTVTVKISQKNS, from human ALDH1A1, at C-terminal (NP_000680.2).

Recognizes human ALDH1A1. Species Crossreactivity: mouse and rat. Species sequence homology: Bovine and canine.

Purified by immunoaffinity chromatography

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

~0.5mg/ml

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-EVKTVTVKISQKNS, from human ALDH1A1, at C-terminal (NP_000680.2). Specificity: Recognizes human ALDH1A1. Species Crossreactivity: mouse and rat. Species sequence homology: Bovine and canine. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

-20°C

1. Dylla SJ, Beviglia L, Park IK, Chartier C, Raval J, Ngan L, Pickell K, Aguilar J, Lazetic S, Smith-Berdan S, Clarke MF, Hoey T, Lewicki J, Gurney AL. 2. Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One. 2008 Jun 18;3(6):e2428. 3. Szatmari I, Pap A, Rühl R, Ma JX, Illarionov PA, Besra GS, Rajnavolgyi E, Dezso B, Nagy L. 4. PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62. 5. Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development. Toxicol Sci. 2006 Feb;89(2):386-98. Epub 2005 Nov 16. 6. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY. 7. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004 Oct;21(4):527-38.

https://usbio-images.r.worldssl.net/prodimages/7/A1334-33X_1.jpg