Activin A Receptor Type IB (ACVR1B, Activin Receptor-like Kinase 4, Activin Receptor Type 1B Precursor, ACTR-IB, ACVRLK4, ALK4) | US Biological A0855-90F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Activin A Receptor Type IB (ACVR1B, Activin Receptor-like Kinase 4, Activin Receptor Type 1B Precursor, ACTR-IB, ACVRLK4, ALK4)

catalog :

A0855-90F

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

A0855-90F

Product wo Prefix :

Activin A Receptor Type IB (ACVR1B, Activin Receptor-like Kinase 4, Activin Receptor Type 1B Precursor, ACTR-IB, ACVRLK4, ALK4)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

The activin A receptor type 1 (ACVR1) is a membrane associated serine/threonine kinase receptor that binds activin A and TGF-beta superfaily growth factors, including bone morphogenetic protein 2 (BMP2) and BMP4, 6 and 7 (1-3). Functional activin receptors are composed of a pair of type I and type II activin receptor proteins. Following ligand binding, ACVR1 is phosphorylated by its type II binding partner, which allows recruitment and activation of receptor regulated SMAD (R-Smad) proteins (4). Phosphorylation of R-Smad proteins results in their translocation to the nucleus where R-Smads activate transcription of target genes (5). Mutations in the corresponding ACVR1 gene are associated with the genetic developmental disorders hereditary hemorrhagic telangiectasia and fibrodysplasia ossificans progressive (6,7). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Hu Mk Mo

Immunogen :

Synthetic peptide corresponding to residues near the C-terminus of human ACVR1 protein.

Specificity :

Recognizes human ACVR1. Species crossreactivity: mouse, monkey

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues near the C-terminus of human ACVR1 protein. Specificity: Recognizes human ACVR1. Species crossreactivity: mouse, monkey Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Attisano, L. et al. (1993) Cell 75, 671-80, 2. Macías-Silva, M. et al. (1998) J Biol Chem 273, 25628-36, 3. Ho, C.C. and Bernard, D.J. (2009) Biol Reprod 81, 133-41, 4. Attisano, L. et al. (1996) Mol Cell Biol 16, 1066-73, 5. Attisano, L. and Wrana, J.L. (2000) Curr Opin Cell Biol 12, 235-43, 6. Shore, E.M. et al. (2006) Nat Genet 38, 525-7, 7. Letteboer, T.G. et al. (2005) Hum Genet 116, 8-16.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/39/A0855-90F_1.jpg