Tissue Inhibitor of Metalloproteinases 3 (TIMP Metallopeptidase Inhibitor 3, TIMP3, TIMP-3)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Tissue Inhibitor of Metalloproteinases 3 (TIMP Metallopeptidase Inhibitor 3, TIMP3, TIMP-3)

catalog :

138599

quantity :

20 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

138599

Product wo Prefix :

Tissue Inhibitor of Metalloproteinases 3 (TIMP Metallopeptidase Inhibitor 3, TIMP3, TIMP-3)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

20 ug

Isotype :

IgG

Desc1 :

TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP's inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunofluorescence, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 0.5-1ug/10e6 cells Immunofluorescence: 1-2ug/ml Western Blot: 0.5-1ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 1-2ug/ml/30min @ RT Immunoprecipitation: 1-2ug/500ug protein lysate Optimal dilutions to be determined by the researcher. Positive Control: Placenta or breast carcinoma Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Bo Ca Eq Hu Mo Rt

Immunogen :

Peptide corresponding to aa175-211 from TIMP3. Species Sequence Homology: mouse, rat

Specificity :

Recognizes human TIMP3. Species Crossreactivity: mouse, rat, bovine, canine and equine.

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. Also available without BSA and azide, see 138599-AF.

Concentration :

~0.2mg/ml

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: ~0.2mg/ml Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. Also available without BSA and azide, see 138599AF. Purity: Purified by Protein A affinity chromatography. Immunogen: Peptide corresponding to aa175-211 from TIMP3. Species Sequence Homology: mouse, rat Specificity: Recognizes human TIMP3. Species Crossreactivity: mouse, rat, bovine, canine and equine. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FC IF IHC IP WB

Storage Temperature :

-20°C

Reference :

1. Nagase, H. et al. (2006) Cardiovasc Res 69, 562-73. 2. Visse, R. and Nagase, H. (2003) Circ Res 92, 827-39.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/8/138599_1.jpg