Chorionic Gonadotropin, Human, beta (hCG beta) | US Biological 138531 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Chorionic Gonadotropin, Human, beta (hCG beta)

catalog :

138531

quantity :

20 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HCGb/54

The same clone is also sold as:

Abnova: MAB11284
Abcam: ab187285, ab212279

reactivity :

human

product information

Catalog Number :

138531

Product wo Prefix :

Chorionic Gonadotropin, Human, beta (hCG beta)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

20 ug

Clone # USB :

HCGb/54

Isotype :

IgG1,k

Desc1 :

This monoclonal antibody reacts with a protein of 22kD, identified as bet a sub-unit of HCG. It does not cross react with the alpha sub-unit. HCG is a glycoprotein, which is secrete d in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide cha ins designated as the alpha and beta subunits. The alpha subunit is identical to that of thyroid stim ulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG monoclonal antibody detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarc inoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of l ung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (FFPE): 0.5-1ug/ml. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes Optimal dilutions to be determined by the researcher. Positive Control: JAR or TT cells, Placenta Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

Full-length recombinant protein corresponding to human hCG-beta. Cellular Localization: Cytoplasmic, secreted

Specificity :

Recognizes human hCG beta.

Purity :

Purified by Protein A/G affinity chromatography.

Form :

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. Also available without BSA and azide, see 138531-AF.

Concentration :

~0.2mg/ml

Desc2 :

Product Type: Mab Isotype: IgG1,k Clone No: HCGb/54 Host: mouse Source: human Concentration: ~0.2mg/ml Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. Also available without BSA and azide, see 138531-AF. Purity: Purified by Protein A/G affinity chromatography. Immunogen: Full-length recombinant protein corresponding to human hCG-beta. Cellular Localization: Cytoplasmic, secreted Specificity: Recognizes human hCG beta. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

IHC

Storage Temperature :

-20°C

Reference :

1. Cocquebert M et. al. Am J Physiol Endocrinol Metab. 2012;303(8) :E950-8.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/30/138531_1.jpg