This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
US Biological
product type :
antibody
product name :
CD79a (B Cell Antigen Receptor Complex-associated Protein Alpha Chain) discontinued
catalog :
138527
quantity :
100 ul
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
JCB117

The same clone is also sold as:
reactivity :
human
product information
Catalog Number :
138527
Product wo Prefix :
CD79a (B Cell Antigen Receptor Complex-associated Protein Alpha Chain) discontinued
Host :
mouse
Product Type :
Mab
Category :
Antibodies
Size1 :
100 ul
Clone # USB :
JCB117
Isotype :
IgG1,k
Desc1 :
A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well. Applications: Suitable for use in Flow Cytometry, Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 5-10ul/10e6 cells Immunofluorescence: 1:50-1:100 Western Blot: 1:100-1:200 Immunohistochemistry (Frozen & Formalin fixed paraffin embedded): 1:100-1:200/30min @ RT Immunoprecipitation: 5-10ul/500ug protein lysate Optimal dilutions to be determined by the researcher. Positive Control: Daudi or Ramos cells. Germinal center B-cells in a lymph node or tonsil. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Hu
Immunogen :
Synthetic peptide corresponding to aa202-216 (GTYQDVGSLNIADVQ) from human CD79a.
Specificity :
Recognizes human CD79a.
Purity :
Supernatant
Form :
Supplied as a liquid, 0.05% sodium azide.
Concentration :
Not determined
Desc2 :
Product Type: Mab Isotype: IgG1,k Clone No: JCB117 Host: mouse Source: human Concentration: Not determined Form: Supplied as a liquid, 0.05% sodium azide. Purity: Supernatant Immunogen: Synthetic peptide corresponding to aa202-216 (GTYQDVGSLNIADVQ) from human CD79a. Specificity: Recognizes human CD79a. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
FC IF IHC IP WB
Storage Temperature :
-20°C
Reference :
1. Polson AG, Yu SF, et al., Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma. Blood. 2007 Jul 15;110(2):616-23. Epub 2007 Mar 20. PMID: 17374736 2. Duncan L, Webster K, et al., Vet Immunol Immunopathol. 2010 Aug 15;136(3-4):235-47. doi: 10.1016/j.vetimm.2010.03.013. Epub 2010 Mar 25. PMID: 20399507 3. Haggart R, Perera J, Huang H. Cloning of a hamster anti-mouse CD79B antibody sequences and identification of a new hamster immunoglobulin lambda constant IGLC gene region. Immunogenetics. 2013 Apr 5. [Epub ahead of print] PMID: 23558558 4. Huang X, Takata K, et al., Pathol Int. 2011 Mar;61(3):122-9. doi: 10.1111/j.1440-1827.2010.02634.x. Epub 2011 Jan 11. PMID: 21355953 5. Chu PG, Arber DA. CD79: a review. Appl Immunohistochem Mol Morphol. 2001 Jun;9(2):97-106. Review. PMID: 11396639
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/11/138527_1.jpg
company information
US Biological
4 Technology Way
Salem, MA01970
service@usbio.net
https://www.usbio.net
800-520-3011
headquarters: USA
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